Primary bilateral renal diffuse large B-cell lymphoma with central nervous system metastases in a captive brown bear (Ursus arctos) - a case report
Ana Beck , Slaven Reljić , Ivan-Conrado Šoštarić-Zuckermann , Marcin Wrzosek , Doroteja Huber
AbstractWe present the first report of primary bilateral renal diffuse large B-cell lymphoma with central nervous system metastases, in a 7 year-old, captive female brown bear. After 7 months of progressive neurological disease, the animal was euthanized. On necropsy, neoplastic nodules with infiltrative growth in the kidneys were found. Neoplastic proliferation of a similar pattern was found compressing the cerebellum and brain stem, and growing through the nervus maxillaris and nervus ophtalmicus. Histology revealed a highly cellular round cell neoplasm, with an infiltrative diffuse growth pattern through the kidneys and nervous parenchyma. On immunohistochemistry, the neoplastic cells stained for the B-cell marker Pax-5. Our report suggests that lymphoma should be considered as a differential diagnosis in bears with a chronic progressive neurological disease. © 2016 University of Zagreb, Facultty of Veterinary Medicine.
|Other language title versions||Primarni obostrani difuzni B-velikostanični limfom bubrega s metastazama u središnjem živčanom sustavu u smeđe medvjedice (Ursus arctos) držane u zatočeništvu|
|Journal series||VETERINARSKI ARHIV, ISSN 0372-5480, (A 15 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Brown bear; Ursus arctos; Primary renal large B-cell lymphoma; Central nervous system metastases, pathology; Pathology; Smeđa medvjedica; Ursus arctos; Primarni difuzni B-velikostanični limfom; Bubreg; Metastaze; Središnji živčani sustav; Patologija|
|Score|| = 15.0, 22-04-2021, ArticleFromJournal|
= 15.0, 22-04-2021, ArticleFromJournal
|Publication indicators||= 1; = 1; : 2016 = 0.718; : 2016 = 0.302 (2) - 2016=0.458 (5)|
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