Flax oil from transgenic Linum usitatissimum selectively inhibits in vitro proliferation of human cancer cell lines
Tomasz Gębarowski , Katarzyna Gębczak , Benita Wiatrak , Anna Kulma , Katarzyna Pelc , Tadeusz Czuj , Jan Szopa , Kazimierz Gąsiorowski
AbstractEmulsions made of oils from transgenic flaxseeds significantly decreased in vitro proliferation of six tested human cancer cell lines in 48-h cultures, as assessed with the standard sulforhodamine assay. However, the emulsions also increased proliferation rate of normal human dermal fibroblasts and, to a lower extend, of keratinocytes. Both inhibition of in vitro proliferation of human cancer cell lines and stimulation of proliferation of normal dermal fibroblasts and keratinocytes were especially strong with the emulsion type B and with emulsion type M. Oils from seeds of transgenic flax type B and M should be considered as valuable adjunct to standard cytostatic therapy of human cancers and also could be applied to improve the treatment of skin lesions in wound healing.
|Journal series||Acta Poloniae Pharmaceutica, ISSN 0001-6837, e-ISSN 2353-5288, (A 15 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||transgenic flax seeds; oil emulsions; in vitro proliferation; cancer cells; normal skin cells|
|Score||= 15.0, 20-08-2020, ArticleFromJournal|
|Publication indicators||= 0; = 1; : 2017 = 0.46; : 2017 = 0.531 (2) - 2017=0.884 (5)|
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