Synthesis and anticancer activity of novel halolactones with β-aryl substituents from simple aromatic aldehydes
Witold Gładkowski , Andrzej Skrobiszewski , Marcelina Mazur , Monika Siepka , Aleksandra Pawlak , Bożena Obmińska-Mrukowicz , Agata Białońska , Dominik Poradowski , Angelika Drynda , Mariusz Urbaniak
AbstractA series of 20 novel racemic iodo-, bromo- and chlorolactones, possessing β-phenyl-γ-lactone or β-phenyl-δ-lactone framework, were synthesized from commercially available aromatic aldehydes in convenient five-step syntheses. Some of them showed noticeable cytotoxic effect against two cancer lines, Jurkat (human leukaemia) and D17 (canine osteosarcoma). The highest activity, comparable with carboplatin, was observed for cis-5-(1-iodoethyl)-4-(4′-isopropylphenyl)dihydrofuran-2-one against Jurkat cell line.
|Journal series||Tetrahedron, ISSN 0040-4020, (A 30 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Lactones; Aromatic ring; Halolactonization; Cytotoxic activity|
|ASJC Classification||; ;|
|Score|| = 30.0, 14-07-2020, ArticleFromJournal|
= 30.0, 14-07-2020, ArticleFromJournal
|Publication indicators||= 20; = 31; : 2014 = 0.905; : 2013 = 2.817 (2) - 2013=2.772 (5)|
|Citation count*||36 (2020-09-21)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.