Superabsorbent crosslinked bacterial cellulose biomaterials for chronic wound dressings
Daria Ciecholewska-Juśko , Anna Żywicka , Adam Junka , Radosław Drozd , Peter Sobolewski , Paweł Migdał , Urszula Kowalska , Monika Toporkiewicz , Karol Fijałkowski
AbstractIn this work, we present a novel ex situ modification of bacterial cellulose (BC) polymer, that significantly improves its ability to absorb water after drying. The method involves a single inexpensive and easy-to-perform process of BC crosslinking, using citric acid along with catalysts, such as disodium phosphate, sodium bicarbonate, ammonium bicarbonate or their mixtures. In particular, the mixture of disodium phosphate and sodium bicarbonate was the most promising, yielding significantly greater water capacity (over 5 times higher as compared to the unmodified BC) and slower water release (over 6 times as compared to the unmodified BC). Further, our optimized crosslinked BC had over 1.5x higher water capacity than modern commercial dressings dedicated to highly exuding wounds, while exhibiting no cytotoxic effects against fibroblast cell line L929 in vitro. Therefore, our novel BC biomaterial may find application in super-absorbent dressings, designed for chronic wounds with imbalanced moisture level.
|Journal series||Carbohydrate Polymers, ISSN 0144-8617, e-ISSN 1879-1344, (N/A 140 pkt)|
|Keywords in English||Bacterial cellulose, Biopolymer, Crosslinking, Water-related properties, Wound dressings|
|ASJC Classification||; ;|
|Score||= 140.0, 25-01-2021, ArticleFromJournal|
|Publication indicators||= 0; : 2018 = 1.72; : 2019 = 7.182 (2) - 2019=6.89 (5)|
|Citation count*||6 (2021-04-30)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.