Effects of advanced age and pituitary pars intermedia dysfunction on components of the acute phase reaction in horses
Agnieszka Żak , Natalia Siwińska , S. Elzinga , V.D. Barker , Tadeusz Stefaniak , B.J. Schanbacher , N.J. Place , Artur Niedźwiedź , Amanda Adams
AbstractAge, neurodegenerative disorders, and dysfunction of insulin secretion may be correlatedwith increased systemic concentrations of acute phase markers. Thus, the study aimed todetermine the effect of age, pituitary pars intermedia dysfunction (PPID), and insulindysregulation (ID) associated with PPID, on markers of the acute phase reaction. Twenty-nine mix-breed horses of both sexes were classified into groups: (1) healthy adult controls,(2) healthy non-PPID geriatric horses, (3) PPID IDþhorses, and (4) PPID ID horses. Wholeblood proinflammatory cytokine gene expression and serum concentrations of pro- andanti-inflammatory cytokines and acute phase proteins were measured. The data wereanalyzed using the Mann–WhitneyU-test, and correlations between groups of data wereassessed using Spearman’s correlation coefficient. The tests were statistically significant ifP<0.05. No differences in the whole blood cytokine gene expression, serum cytokineconcentrations, or acute phase proteins were noted between the groups. In the PPID IDgroup, there was a strong correlation between the ACTH concentration after the admin-istration of thyrotropin-releasing hormone and the expression of IL-8 (r¼0.941;P¼0.0321). In the PPID IDþgroup, there was a strong correlation between basal insulinconcentrations and serum amyloid A (SAA; r¼0.936;P¼0.0083) as well as betweenpostprandial insulin concentrations and SAA (r¼0.965;P¼0.001). These data suggestthat neurodegeneration in horses moderately affects circulating markers of inflammationand that ID in horses with PPID influences acute phase inflammatory markers.
|Journal series||Domestic Animal Endocrinology, ISSN 0739-7240, e-ISSN 1879-0054, (N/A 70 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Equine Cushing’s disease, Neurodegeneration, Geriatric, Insulin, Inflammation, SAA|
|ASJC Classification||; ;|
|License||Journal (articles only); published final; ; with publication|
|Score||= 70.0, 08-07-2020, ArticleFromJournal|
|Publication indicators||= 1; = 1; : 2018 = 0.955; : 2018 = 2.302 (2) - 2018=2.063 (5)|
|Citation count*||1 (2020-07-04)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.