Fungistatic activity of bicyclo[4.3.0]-γ-lactones
Teresa Olejniczak , Filip Boratyński , Agata Białońska
AbstractFive optically active and sixteen racemic lactones (nine of them new) of bicyclo[4.3.0]nonane structure were synthesized. IC50 values for the following phytopathogens were determined: Aspergillus ochraceus AM 456, Fusarium culmorum AM 282, Fusarium oxysporum AM 13, Fusarium tricinctum AM 16. Effect of compound structures, especially stereogenic centers, on fungistatic activity has been discussed. The highest fungistatic activity was observed for trans-7,8-dibromo-cis-3-oxabicyclo[4.3.0]nonan-2-one (3c), IC50 = 30.1 μg/mL (0.10 μM/mL), and cis-7,8-epoxy-cis-3-oxabicyclo[4.3.0]nonan-2- one (3b), IC50 = 72.2 μg/mL (0.47 μM/mL), toward F. oxysporum AM 13. © 2011 American Chemical Society.
|Journal series||Journal of Agricultural and Food Chemistry, ISSN 0021-8561, e-ISSN 1520-5118, (A 45 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||lactones; IC50; HLADH; Fusarium oxysporum; Fusarium culmorum|
|Publication indicators||= 13; = 13; : 2011 = 1.445; : 2011 = 2.823 (2) - 2011=3.239 (5)|
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