Whatever makes them stick - adhesins of avian pathogenic Escherichia coli
Adrianna Aleksandrowicz , Muhammad Moman Khan , K. Sidorczuk , M. Noszka , Rafał Kolenda
AbstractAvian pathogenic Escherichia coli (APEC) is associated with extraintestinal infections and the development of colibacillosis, causing high mortality in farm birds and extensive losses in the poultry industry worldwide. The virulence of APEC is a complex phenomenon associated with numerous mechanisms involving a variety of extracellular and intracellular structures to overcome host barriers. Initial bacterial attachment or adhesion to host cells is vital to bacterial pathogenesis and is determined by various adhesins. These proteins protect pathogens against possible host defense mechanisms, enabling the effective use of other virulence attributes. Considering this property, the current review provides a systematic and in-depth analysis of the latest information on adhesins analyzed in APEC strains. This review discusses in detail each of the adhesin types, such as fimbrial chaperone-usher, fimbrial curli, nonfimbrial and atypical adhesins, and their components, presenting an opportunity to gain a better understanding of different adhesins and mechanisms employed in pathogenesis. Additionally, the article scrutinizes and notes missing information and potential studies that need to be undertaken to develop a complete understanding of APEC adhesion.
|Journal series||Veterinary Microbiology, ISSN 0378-1135, e-ISSN 1873-2542, (N/A 100 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||APEC; Adhesin; Escherichia coli; Fimbriae; Colibacillosis; Avian; Poultry; Adhesion|
|ASJC Classification||; ;|
|License||Journal (articles only); published final; ; with publication|
|Score||= 100.0, 10-05-2021, ArticleFromJournal|
|Publication indicators||: 2016 = 1.208; : 2019 = 3.03 (2) - 2019=2.923 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.