Impact of Liposomal Drug Formulations on the RBCs Shape, Transmembrane Potential, and Mechanical Properties
Sylwia Cyboran-Mikołajczyk , Przemysław Sareło , Robert Pasławski , Urszula Pasławska , Magdalena Przybyło , Kacper Nowak , Michał Płóciennik , Podbielska Halina , Marta Kopaczyńska , Magdalena Wawrzyńska
AbstractLiposomal technologies are used in order to improve the effectiveness of current therapies or to reduce their negative side effects. However, the liposome–erythrocyte interaction during the intravenous administration of liposomal drug formulations may result in changes within the red blood cells (RBCs). In this study, it was shown that phosphatidylcholine-composed liposomal formulations of Photolon, used as a drug model, significantly influences the transmembrane potential, stiffness, as well as the shape of RBCs. These changes caused decreasing the number of stomatocytes and irregular shapes proportion within the cells exposed to liposomes. Thus, the reduction of anisocytosis was observed. Therefore, some nanodrugs in phosphatidylcholine liposomal formulation may have a beneficial effect on the survival time of erythrocytes.
|Journal series||International Journal of Molecular Sciences, ISSN 1422-0067, (N/A 140 pkt)|
|Publication size in sheets||0.55|
|Keywords in English||shape of erythrocytes; anisocytosis; Photolon; phosphatidylcholine liposomes; monolayer liposome formulations; biomechanical properties; transmembrane potential; osmotic resistance; drug carrier|
|ASJC Classification||; ; ; ; ; ; ;|
|License||Journal (articles only); published final; ; with publication|
|Score||= 140.0, 28-04-2021, ArticleFromJournal|
|Publication indicators||= 0; = 0; : 2018 = 1.224; : 2018 = 4.183 (2) - 2018=4.331 (5)|
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