Manufacturing of peptides exhibiting biological activity
Aleksandra Zambrowicz , Monika Timmer , Antoni Polanowski , Gert Lubec , Tadeusz Trziszka
Numerous studies have shown that food proteins may be a source of bioactive peptides. Those peptides are encrypted in the protein sequence. They stay inactive within the parental protein until release by proteolytic enzymes (Mine and Kovacs-Nolan in Worlds Poult Sci J 62(1):87-95, 2006; Hartman and Miesel in Curr Opin Biotechnol 18:163-169, 2007). Once released the bioactive peptides exhibit several biofunctionalities and may serve therapeutic roles in body systems. Opioid peptides, peptides lowering high blood pressure, inhibiting platelet aggregation as well as being carriers of metal ions and peptides with immunostimulatory, antimicrobial and antioxidant activities have been described (Hartman and Miesel in Curr Opin Biotechnol 18:163-169, 2007). The biofunctional abilities of the peptides have therefore aroused a lot of scientific, technological and consumer interest with respect to the role of dietary proteins in controlling and influencing health (Möller et al. in Eur J Nutr 47(4):171-182, 2008). Biopeptides may find wide application in food production, the cosmetics industry as well as in the prevention and treatment of various medical conditions. They are manufactured by chemical and biotechnological methods (Marx in Chem Eng News 83(11):17-24. 2005; Hancock and Sahl in Nat Biotechnol 24(12):1551-1557, 2006). Depending on specific needs (food or pharmaceutical industry) different degrees of peptide purifications are required. This paper discusses the practicability of manufacturing bioactive peptides, especially from food proteins. © 2012 The Author(s).
|Journal series||Amino Acids, ISSN 0939-4451, (A 30 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Bioactive peptides, Enzymatic hydrolysis, Immunostimulatory activity, Ovokinin|
|ASJC Classification||; ;|
|Score|| = 30.0, 09-09-2020, ArticleFromJournal|
= 30.0, 09-09-2020, ArticleFromJournal
|Publication indicators||= 58; = 52; : 2013 = 1.128; : 2013 = 3.653 (2) - 2013=3.489 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.