Diagnostic accuracy of interleukin-6 levels in peritoneal fluid for detection of endometriosis
Dorota Wickiewicz , Agnieszka Chrobak , Grzegorz B. Gmyrek , Alicja Halbersztadt , Marian S. Gabryś , Marian Goluda , Anna Chełmońska-Soyta
Purpose: To determine, with extended receiver operating characteristic (ROC) curve analysis, the diagnostic value of cytokines showing significantly different peritoneal concentrations between women with and without endometriosis. Methods: Multiplex cytokine concentration measurement of IL-2, IL-4, IL-6, IL-10, TNF-α and IFN-γ levels in peritoneal fluid of women with minimal to mild (n = 10) and moderate to severe (n = 26) endometriosis, and 42 controls. Results: Only IL-6 and IL-10 concentrations were significantly higher in endometriosis patients than in controls. Specifically, significantly higher IL-6 and IL-10 levels were found in moderate to severe but not in minimal to mild endometriosis as compared to controls. For evaluation of diagnostic significance, ROC analysis determined discriminating parameters for IL-6, while those calculated for IL-10 were useless. Importantly, ROC analysis for IL-6 levels limited to women with moderate to severe endometriosis showed the highest area under the curve with the sample size sufficient to achieve 90 % power of the test. Finally, extended ROC including cost of analysis for this group of patients determined the optimal cut-off leading to high specificity and positive likelihood ratio resulting in 79 % effectiveness of the test. Conclusions: While our outcomes show moderate usefulness of peritoneal IL-6 levels in discrimination of moderate to severe endometriosis, further studies might be needed to determine the usefulness of peritoneal IL-6 levels in detection of early stages of endometriosis, as such a finding would be more relevant in clinical decision making. © 2013 Springer-Verlag Berlin Heidelberg.
|Journal series||Archives of Gynecology and Obstetrics, ISSN 0932-0067, (A 20 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||AUC, Endometriosis, Interleukin-10, Interleukin-6, ROC|
|Score|| = 20.0, 21-07-2020, ArticleFromJournal|
= 20.0, 21-07-2020, ArticleFromJournal
|Publication indicators||= 23; = 22; : 2013 = 0.956; : 2013 = 1.279 (2) - 2013=1.194 (5)|
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