Allometric analysis of tylosin tartrate pharmacokinetics in growing male turkeys
Błażej Poźniak , Marta Tikhomirov , Karolina Motykiewicz-Pers , Kamila Bobrek , Marcin Świtała
AbstractBackground: Despite common use of tylosin in turkeys, the pharmacokinetic (PK) data for this drug in turkeys is limited. Within a few months of growth, PK of drugs in turkeys undergoes changes that may decrease their efficacy due to variable internal exposure. Objectives: The objective of this study was to investigate the influence of age on the PK of a single intravenous (i.v.) and oral administration of tylosin to turkeys at a dose of 10 and 50 mg/kg, respectively. Methods: Plasma drug concentrations were measured using high-performance liquid chromatography with UV detection. The PK parameters were assessed by means of noncompartmental approach and were subjected to allometric analysis. Results: During a 2.5-month-long period of growth from 1.4 to 14.7 kg, the median value for area under the concentration-time curve after i.v. administration increased from 2.61 to 7.15 mg × h/L and the body clearance decreased from a median of 3.81 to 1.42 L/h/kg. Over the same time, the median elimination half-life increased from 1.03 to 2.96 h. For the oral administration a similar trend was noted but the differences were less pronounced. Bioavailability was variable (5.76%–21.59%) and age-independent. For both routes, the plasma concentration of the major tylosin metabolite, tylosin D, was minimal. Protein binding was age-independent and did not exceed 50%. Allometric analysis indicated a relatively poor predictivity of clearance, volume of distribution and elimination half-life for tylosin in turkeys. Conclusions: Age has a significant impact on tylosin PK in turkeys and dosage adjustment may be needed, particularly in young individuals.
|Journal series||Journal of Veterinary Science, ISSN 1229-845X, e-ISSN 1976-555X, (N/A 100 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Tylosin; Turkey; allometry; pharmacokinetics; growth|
|License||Journal (articles only); published final; ; with publication|
|Score||= 100.0, 29-06-2020, ArticleFromJournal|
|Publication indicators||= 0; : 2018 = 0.826; : 2018 = 1.503 (2) - 2018=1.573 (5)|
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