Visual and quantitative electroencephalographic analysis of healthy young and adult cats under medetomidine sedation
Marcin Wrzosek , Józef Nicpoń , Luciana Bergamasco , Federica Sammartano , Sigitas Cizinauskas , André Jaggy
AbstractA study was designed to investigate the effect of medetomidine sedation on quantitative electroencephalography (q-EEG) in healthy young and adult cats to determine objective guidelines for diagnostic EEG recordings and interpretation. Preliminary visual examination of EEG recordings revealed high-voltage low-frequency background activity. Spindles, k-complexes and vertex sharp transients characteristic of sleep or sedation were superimposed on a low background activity. Neither paroxysmal activity nor EEG burst-suppression were observed. The spectral analysis of q-EEG included four parameters, namely, relative power (%), and mean, median and peak frequency (Hz) of all four frequency bands (delta, theta, alpha and beta). The findings showed a prevalence of slow delta and theta rhythms as opposed to fast alpha and beta rhythms in both young (group A) and adult (group B) cats. A posterior gradient was reported for the theta band and an anterior gradient for the alpha and beta bands in both groups, respectively. The relative power value in group B compared to group A was significantly higher for theta, alpha and beta bands, and lower for the delta band. The mean and median frequency values in group B was significantly higher for delta, theta and beta bands and lower for the alpha band. The study has shown that a medetomidine sedation protocol for feline EEG may offer a method for investigating bio-electrical cortical activity. The use of q-EEG analysis showed a decrease in high frequency bands and increased activity of the low frequency band in healthy cats under medetomidine sedation.
|Journal series||Veterinary Journal, ISSN 1090-0233, e-ISSN 1532-2971, (A 45 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Cats; Electroencephalogram; Medetomidine; Quantitative electroencephalography; Spectral analysis|
|Publication indicators||= 17; = 17; : 2014 = 1.09; : 2009 = 2.323 (2) - 2009=2.379 (5)|
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