Effect of Physical Training on the Levels of Sex Hormones and the Expression of Their Receptors in Rats With Induced Mammary Cancer in Secondary Prevention Model – Preliminary Study
Katarzyna Siewierska , Iwona Malicka , Christopher Kobierzycki , Jędrzej Grzegrzółka , Aleksandra Piotrowska , Urszula Pasławska , Marek Cegielski , Marzenna Podhorska-Okołów , Piotr Dzięgiel , Marek Woźniewski
AbstractBackground/Aim: Breast cancer is the most common malignant tumor among women worldwide. In previous work, we presented results of physical activity in primary prevention in a model of induced mammary gland cancer. In the present study, we assessed the influence of physical activity on sex hormone levels (estradiol and progesterone) and the expression of their receptors (ER, PR), as well as the level of apoptosis of tumor cells in secondary prevention. Materials and Methods: Fifty 1-month-old female Sprague-Dawley rats received intraperitoneal injection of 180 mg/kg body weight of N-methyl-N-nitrosourea (MNU) for tumor induction. Three months after the administration of MNU, rats were divided into four groups: low-intensity, moderate-intensity, and high-intensity physical training groups (combined as PT) and a sedentary control (SC) group. Physical training was conducted 5 days per week with a three-position treadmill according to a precisely described protocol.
|Journal series||In Vivo, ISSN 0258-851X, e-ISSN 1791-7549, (N/A 40 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Estrogen receptor; progesterone receptor; estradiol; progesterone; breast cancer; physical activity; N-methyl-N-nitrosourea; rat experimental model|
|License||Journal (articles only); published final; ; with publication|
|Score||= 40.0, 15-09-2020, ArticleFromJournal|
|Publication indicators||= 0; : 2018 = 0.548; : 2018 = 1.609 (2) - 2018=1.344 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.