The First Application of Nanoelectrochemotherapy in Feline Oral Malignant Melanoma Treatment - Case Study
Joanna Tunikowska , Agnieszka Antończyk , Nina Rembiałkowska , Łukasz Juźwiak , Vitalij Novickij , Julita Kulbacka
AbstractBackground: The aim of this study was to present the first domestic animal trial of nanosecond electroporation with chemotherapy and CO2 laser surgery. Methods: sixteen-year-old domestic cat with diagnosed melanoma on oral cavity was the case used in the study. Firstly, CO2 laser surgery was used for the removal of most of tumor mass. Then nanoelectrochemotherapy with bleomycin was applied including appropriate margin of healthy tissue. A 15 ± 4 kV/cm × 15 ns pulsing protocol was employed with a total of 800 ± 100 pulses. Only one session of nanoelectrochemotherapy (nanoECT) was performed. Results and conclusions: during the next two weeks areas of focal necrosis were replaced by the granulation tissue. Complete wound healing was observed four weeks after initial treatment. After 15 weeks post treatment, no local recurrence was apparent.
|Journal series||Animals, ISSN 2076-2615, e-ISSN 2076-2615, (N/A 100 pkt)|
|Publication size in sheets||0.3|
|Keywords in English||feline melanoma; electrochemotherapy; nanosecond pulsed electric field; CO2 laser|
|License||Journal (articles only); author's original; ; after publication|
|Score||= 100.0, 10-05-2021, ArticleFromJournal|
|Publication indicators||= 2; = 1; : 2018 = 1.148; : 2019 = 2.323 (2)|
|Citation count*||2 (2021-05-13)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.