Multifunctional nanocrystalline calcium phosphates loaded with Tetracycline antibiotic combined with human adipose derived mesenchymal stromal stem cells (hASCs)
Krzysztof Marycz , Robert Pązik , K. Zawisza , K. Wiglusz , Monika Marędziak , P. Sobierajska , Rafał Wiglusz
AbstractOsteoconductive drug delivery system composed of nanocrystalline calcium phosphates (Ca-10(PO4)(6)(OH)(2)/beta-Ca-3(PO4)(2)) co-doped with Yb3+/Er3+ ions loaded with Tetracycline antibiotic (TC) was developed. Their effect on human adipose derived mesenchymal stromal stem cells (hASCs) as a potential reconstructive biomaterial for bone tissue regeneration was studied. The XRD and TEM measurements were used in order to determine the crystal structure and morphology of the final products. The characteristics of nanocomposites with the TC and hASCs as potential regenerative materials as well as the antimicrobial activity of the nanoparticles against: Staphylococcus aureus ATCC 25923 as a model of the Gram-positive bacteria, Escherichia coli ATCC 8739 of the Gram-negative bacteria, were shown. These combinations can be a promising material for theranostic due to its regenerative, antimicrobial and fluorescent properties. (C) 2016 Elsevier B.V. All rights reserved.
|Journal series||Materials Science & Engineering C - Materials for Biological Applications, ISSN 0928-4931, (A 30 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Mesenchymal stem cells; Regenerative medicine; Up-conversion; Apatites - calcium phosphates; Nanotechnology|
|ASJC Classification||; ; ;|
|Score|| = 30.0, 10-05-2021, ArticleFromJournal|
= 30.0, 10-05-2021, ArticleFromJournal
|Publication indicators||= 15; = 14; : 2016 = 1.335; : 2016 = 4.164 (2) - 2016=3.926 (5)|
|Citation count*||17 (2021-06-08)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.