Microstructure and Mechanical Properties of PU/PLDL Sponges Intended for Grafting Injured Spinal Cord
Anna Lis-Bartos , Dariusz Szarek , Małgorzata Krok-Borkowicz , Krzysztof Marycz , Włodzimierz Jarmundowicz , Jadwiga Laska
AbstractHighly porous, elastic, and degradable polyurethane and polyurethane/polylactide (PU/PLDL) sponges, in various shapes and sizes, with open interconnected pores, and porosity up to 90% have been manufactured. They have been intended for gap filling in the injured spinal cord. The porosity of the sponges depended on the content of polylactide, i.e., it decreased with the increase of polylactide content. The rise of polylactide content caused an increase of Young modulus and rigidity as well as a more complex morphology of the polyurethane/polylactide blends. The mechanical properties, in vitro toxicity, and degradation in artificial cerebrospinal fluid were tested. Sponges underwent continuous degradation with varying degradation rates depending on the polymer composition. In vitro cell studies with fibroblast cultures proved the biocompatibility of the polymers. Based on the obtained results, the designed PU/PLDL sponges appeared to be promising candidates for bridging gaps within injured spinal cord in further in vitro and in vivo studies.
|Journal series||Polymers, ISSN 2073-4360, (N/A 100 pkt)|
|Publication size in sheets||0.8|
|Keywords in English||polyurethane, polylactide, elastic sponges, biomaterials for nerve regeneration, spinal cord|
|License||Journal (articles only); published final; ; with publication|
|Score||= 100.0, 24-02-2021, ArticleFromJournal|
|Publication indicators||= 0; : 2018 = 1.057; : 2017 = 2.935 (2) - 2017=3.509 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.