Transformation of steroids by Trichoderma hamatum
Agnieszka Bartmańska , Jadwiga Dmochowska-Gładysz
AbstractTrichoderma hamatum KCh25 was used to study the mode of transformation of a series of 3-oxosteroids. This potential has not been previously examined. The strain promoted 1-dehydrogenation, which have been rarely observed in fungi cultures. The metabolism of cortexolone resulted in efficient conversion to 1-dehydrocortexolone, with no other product isolated. The other routes of biotransformations of the substrates included: hydroxylation at equatorial 11α, 6α, and 12β positions, ester bond hydrolysis, oxidation of 17α-hydroxyl group, C-17/C-20 bond scission, and the ring D-lactonization. The correlation between a steroid compound structure and the transformation profile and also succession of the observed reactions has been noticed.
|Journal series||Enzyme and Microbial Technology, ISSN 0141-0229, e-ISSN 1879-0909, (A 30 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||1-Dehydrogenation; Biotransformation; Steroid; Trichoderma hamatum|
|ASJC Classification||; ;|
|Publication indicators||= 24; : 2007 = 1.252; : 2007 = 1.969 (2) - 2007=2.373 (5)|
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