E-test determination of antifungal susceptibility of Candida species isolated from turkeys
Ireneusz Sokół , Stanisław Tokarzewski , Kamila Bobrek , Andrzej Gaweł
AbstractIntroduction: Candida species are a natural component of the intestinal tract microflora, but in favourable conditions they can cause superficial, mucosal, or even systemic candidiasis. Poultry production might be a source of human drug-resistant yeast infections, including Candida spp. The limited data concerning the antifungal susceptibility of poultry Candida isolates prompted us to carry out research to determine the susceptibility of isolates from turkey intestinal tracts. Method and Materials: The beak cavity, crop and cloaca were swabbed of 580 turkeys from 58 flocks in western Poland. The susceptibility tests were conducted using the E-test method with amphotericin B, fluconazole, itraconazole, and voriconazole on 52 isolates of C. albicans, C. catenulata, C. glabrata, C. palmioleophila, C. rugosa, C. krusei and C. lusitaniae. Results: All isolates were susceptible to voriconazole. According to the MIC values obtained for amphotericin B and fluconazole, all Candida spp. isolates were classified as susceptible according to the described breakpoints except for C. krusei, which was the only isolate that was amphotericin B-, fluconazole- and itraconazole-resistant. The susceptibility to itraconazole varied: 11 of the Candida isolates were susceptible (21.1%), 29 were dosedependently susceptible (55.8%), and 12 isolates were resistant (23.1%). Conclusion: There are few resistant strains of Candida in turkeys, and the drug resistance varies. When Candida passes from turkeys to humans, there is a wide range of antifungal treatment options.
|Journal series||Journal of Veterinary Research, [Bulletin of the Veterinary Institute in Pulawy, Journal of Veterinary Research (Poland)], ISSN 2450-7393, e-ISSN 2450-8608, (N/A 40 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||antimicrobials, Candida, E-test, MIC, susceptibility, turkeys|
|License||Journal (articles only); published final; ; with publication|
|Score||= 40.0, 10-05-2021, ArticleFromJournal|
|Publication indicators||= 0; : 2018 = 0.501; : 2019 = 1.039 (2) - 2019=1.009 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.