Numerical Analysis of Deformation and Flow in the Proximal Area of the Urethra
R. Rudzyk , M. Malinowski , A. Mackiewicz , Agnieszka Noszczyk-Nowak , Joanna Skonieczna , Jan Madej
AbstractPathological conditions of a male urethra, including fibrosis, have a mechanical background along the entire length of the urethra. They may be caused by excessive deformation of the urethra locally or globally. The condition of prolonged overload causes abnormal tissue remodelling and, consequently, the formation of a thick layer of scar tissue differentiated from the connective tissue of the urethra. This tissue, which has higher mechanical properties, is not highly deformable and therefore, causes a decrease in the diameter of the urethra, which results in conditions that disturb the natural flow of urine. In this paper, it was decided to determine the deformation conditions in the proximal part of the urethra. The study was conducted in three main stages. Transverse sections of the animal urethral tissues were prepared in order to examine mechanical properties and perform histological examinations. On the basis of these examinations, material models which fitted best for the experimental results were sought. Material constants of the Mooney-Rivlin material model with the best fit ratio were determined for further research. On the basis of histological photographs, a geometrical and numerical model of the urethra was developed. The urethra was tested in a flat state of deformation. The strain and stress fields of the Caucha tensor were examined. The methodology of testing the dynamics of the urine flow in the highly deformable urethra was proposed. This is important for the analysis of the influence of at excessive pressure on pathological tissue remodelling leading to fibrosis.
|Journal series||International Journal of Applied Mechanics and Engineering, ISSN 1425-1655, e-ISSN 2353-9003, [1734-4492], (N/A 20 pkt)|
|Publication size in sheets||0.55|
|Keywords in English||urethra, stress-strain characteristic, FEM, CFD, urinary flow|
|ASJC Classification||; ;|
|License||Journal (articles only); author's original; ; after publication|
|Score||= 20.0, 21-09-2020, ArticleFromJournal|
|Publication indicators||: 2018 = 0.439|
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