Urothelial cancer of the prostate gland. Immunohistochemical analysis of two cases of rare canine cancer
Rafał Ciaputa , Valeria Grieco , Izabela Janus , Małgorzata Kandefer-Gola , Piotr Dzięgiel , Marcin Nowak
AbstractIntroduction. The study aimed to diagnose urothelial cancer of prostate gland (UCPG) in dogs as the primary focus and in its metastasis based on the expression of specific proteins used in immunohistochemical diagnosis of prostate cancer in men. Material and methods . The study was carried out on specimens collected during a post-mortem examination from macroscopic lesions of the prostate glands from two dogs. The immunoexpression of the following proteins was verified: prostate-specific antigen (PSA), high molecular weight cytokeratins, cytokeratin 7 and 20, E-cadherin, von Willebrand factor, cyclooxygenase-2, microsomal PGE2-1 synthase and component of the minichromosome 7 maintenance complex. The following antibodies were used: prostate-specific antigen, high molecular weight cytokeratins, cytokeratin 7 and 20, E-cadherin, von Willebrand factor, cyclooxygenase-2, microsomal PGE2-1 synthase and component of the minichromosome 7 maintenance complex. Results: All markers, except for PSA, were expressed both at the primary tumour site and in the metastasis. Conclusions: The immunohistochemical approach was more useful for the diagnosis of UCPG in dog than typical histopathological staining methods because it allowed for precise determination of features, type and grade of the tumour that may affect its early detection and treatment.
|Journal series||Folia Histochemica et Cytobiologica, ISSN 0239-8508, e-ISSN 1897-5631, (N/A 70 pkt)|
|Publication size in sheets||0.6|
|Keywords in English||canine; prostate; urothelial cancer; metastasis; cell markers; IHC|
|ASJC Classification||; ;|
|License||Journal (articles only); published final; ; with publication|
|Score||= 70.0, 28-04-2021, ArticleFromJournal|
|Publication indicators||= 0; = 0; : 2018 = 0.802; : 2019 = 0.854 (2) - 2019=1.299 (5)|
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