Biological activity and structure dependent properties of cuprous iodide complexes with phenanthrolines and water soluble tris (aminomethyl) phosphanes
Radosław Starosta , Kamila Stokowa , Magdalena Florek , Jarosław Król , Agnieszka Chwiłkowska , Kulbacka Julita , Jolanta Saczko , Jacek Skała , Małgorzata Jezowska-Bojczuk
AbstractThis paper presents the biological activity of copper(I) iodide complexes with 1,10-phenanthroline (phen) or 2,9-dimethyl-1,10-phenanthroline (dmp) and three tris (aminomethyl) phosphanes: P(CH2N(CH2CH 2)2NCH3)3 (1), P(CH 2N(CH2CH2)2O)3 (2) and P (CH2N(CH3)CH2CH2OH)3 (3). Crystallographic and DFT data indicate a significantly stronger binding ability of 3 in the complexes [CuI (phen) P (CH2N (CH3)CH 2CH2OH)3] (3P) and [CuI(dmp)P(CH 2N(CH3)CH2CH2OH)3] (3N) in comparison to the 1 or 2 ligands. Most probably, this is caused by the relatively small steric requirements of 3. The complexes with dmp exhibit a very high in vitro activity against the Staphylococcus aureus strain (MIC - minimal inhibitory concentration: 2.5-5 μg/mL) and Candida albicans diploid fungus (MIC: 1.25-2.5 μg/mL). All the tested complexes also show a strong in vitro antitumor activity against human ovarian carcinoma cell lines: MDAH 2774 (IC50: 7-2 μM) and cisplatin-resistant SCOV 3 (IC50: 3-2 μM). Interestingly, the complexes with dmp of higher biological activity more weakly interact with bovine serum albumin (BSA) and less efficiently cleave the pBluescriptSK+ plasmid.
|Journal series||Journal of Inorganic Biochemistry, ISSN 0162-0134, e-ISSN 1873-3344, (A 35 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Aminomethylphosphanes; Antibacterial, antifungal and anticancer activity; Bovine serum albumin luminescence quenching; Copper(I) complexes; pBluescsriptSK+ plasmid gel electrophoresis|
|Publication indicators||= 34; = 32; : 2011 = 1.303; : 2011 = 3.354 (2) - 2011=3.495 (5)|
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