The effect of propylene glycol and glycerol on carbohydrate and lipid metabolism in rabbits-short communication
Robert Kupczyński , Michał Bednarski , Tomasz Piasecki
AbstractThis study examined the effects of glycogenic precursors (propylene glycol and glycerol) on lipid and carbohydrate metabolism of rabbit does fed a restricted diet. The study included 48 females of the Hyplus genetic line, divided into primiparous and multiparous groups. On the 4th day of the restricted diet, the rabbits were orally administered propylene glycol (PG) or glycerol (G), 2 mL/kg body weight0.75. Blood samples were collected immediately prior to administration of the glycogenic precursors and 30, 60, 90, 180, and 360 minutes thereafter. Serum concentrations of glucose, non-esterified fatty acids (NEFA), and β-hydroxybutyric acid were determined. Following the use of both glycogenic precursors, glucose concentration increased after 30 min., which was maintained until the end of the experiment. A significant (P<0.01) decrease in NEFA occurred 120 min after PG was given to primiparous and multiparous does, and remained low up to 360 min after administration. For glycerol, the decrease in NEFA occurred later after 360 min. The mean glucose concentration for the whole period was lower in multiparous females, and higher in primiparous ones. We revealed that both propylene glycol and glycerol showed the evident effect of lipolysis inhibition and gluconeogenesis stimulation, which can be used in practice (e.g. lactation, reproduction).
|Other language title versions||Učinak propilen-glikola i glicerola na metabolizam ugljikohidrata i masti u kunića - kratko priopćenje|
|Journal series||Veterinarski Arhiv, ISSN 0372-5480, e-ISSN 1331-8055, (N/A 40 pkt)|
|Keywords in English||rabbit; metabolic status; propylene glycol; glycerol|
|License||Journal (articles only); published final; ; with publication|
|Score||= 40.0, 15-09-2020, ArticleFromJournal|
|Publication indicators||= 0; = 0; : 2016 = 0.718; : 2018 = 0.426 (2) - 2018=0.477 (5)|
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