Simple and green method for the extraction of xanthohumol from spent hops using deep eutectic solvents
Aleksandra Grudniewska , Jarosław Popłoński
AbstractSpent hops (SH) are a rich source of the prenylated chalcone, xanthohumol (XN), which has a broad spectrum ofbiological activity. In this study, four choline chloride-based deep eutectic solvents (DESs), which containedglycerol, ethylene glycol, propylene glycol, or lactic acid as a hydrogen bond donor, were tested for the ex-traction of XN from SH. XN-rich precipitates were obtained by the addition of water (as an antisolvent) to theDES extracts. To determine the XN contents, the precipitates were extracted with methanol and then analyzed byHPLC. The highest XN extraction yield (2.30 mg/g SH) was obtained using a DES composed of choline chlorideand propylene glycol (1:2 mol/mol) with 5 wt% water, 1:50 SH/DES (w/w), and 3:1 antisolvent/DES (v/w) at60 °C for 1 h. This DES could be recovered and reused at least three times without significantly decreasing the XNextraction yield. Our results therefore demonstrated that DESs can be considered green, efficient, and promisingsolvents for the extraction of XN from SH. Moreover, the proposed simple DES-based method appears to be aneffective alternative to conventional XN extraction methods.
|Journal series||Separation and Purification Technology, ISSN 1383-5866, e-ISSN 1873-3794, (N/A 140 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Xanthohumol, Deep eutectic solvent (DES), Spent hops, Extraction, Green chemistry|
|License||Journal (articles only); published final; ; with publication|
|Score||= 140.0, 21-09-2020, ArticleFromJournal|
|Publication indicators||= 0; : 2016 = 1.394; : 2018 = 5.107 (2) - 2018=4.551 (5)|
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