The influence of age and body weight gain on enrofloxacin pharmacokinetics in turkeys—Allometric approach to dose optimization
Błażej Poźniak , Marta Tikhomirov , Karolina Motykiewicz-Pers , Kamila Bobrek , Marcin Świtała
AbstractEnrofloxacin is a concentration‐dependent antimicrobial used in bacterial infections in poultry. During a few months of a turkey's life, pharmacokinetics of drugs undergoes substantial changes which may compromise their efficacy due to variability in internal exposure (measured by area under the concentration–time curve, AUC). The aim of this study was to describe the effects of age on the pharmacokinetics of a single intravenous (i.v.) and oral administration of enrofloxacin at a dose of 10 mg/kg to turkeys. It was found that during a 2.5‐month‐long period of growth from 1.4 to 14.6 kg, the AUC after i.v. administration increased almost threefold due to a significant decrease in the body clearance (from a mean of 0.76–0.28 L hr−1 kg−1). Over the same period, the mean elimination half‐life was prolonged from 2.65 to 7.03 hr. Oral administration resulted in a similar trend in pharmacokinetic parameters. For both routes, formation of the major metabolite, ciprofloxacin, was marginal. Protein binding was not age‐dependent and never exceeded 50%. Body clearance, volume of distribution and elimination half‐life were subjected to an allometric analysis and a novel, nonlinear dosage protocol has been proposed to improve the internal exposure to the drug in different age groups of turkeys.
|Journal series||Journal of Veterinary Pharmacology and Therapeutics, ISSN 0140-7783, e-ISSN 1365-2885, (N/A 70 pkt)|
|Publication size in sheets||0.55|
|Keywords in English||allometry, dose optimization, enrofloxacin, pharmacokinetics, turkeys|
|Score||= 70.0, 15-09-2020, ArticleFromJournal|
|Publication indicators||= 0; = 1; : 2018 = 0.861; : 2018 = 1.175 (2) - 2018=1.397 (5)|
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