Effects of a skullcap root supplement on haematology, serum parameters and antioxidant enzymes in rabbits on a high-cholesterol diet
Bożena Króliczewska , Dorota Miśta , Wojciech Zawadzki , A. Wypchło , Jarosław Króliczewski
AbstractWe studied the effects of Scutellaria baicalensis root on blood parameters and antioxidant enzyme activities in rabbits fed a high-cholesterol diet. Thirty-two New Zealand White rabbits were divided into four groups of eight animals each. They were fed a standard diet (C group), a diet with a 1% pure cholesterol supplement (CH group), a diet with a 1% pure cholesterol supplement and a 9% skullcap root supplement (CH + SR group), or a diet with a 9% skullcap root supplement (SR group). After 6 weeks, the rabbits fed the high-cholesterol diet had significantly decreased RBC and Hb levels and significantly increased MCV, MCH and Fe levels (p ≤ 0.05). The skullcap root supplement had no adverse effects on the haematological parameters. The values for RBC, Hb, HCT, MCV, MCH and MCHC were similar in the skullcap root-treated and control rabbits. We also observed a remarkable elevation in the serum TC, LDL and TG levels at the end of the 6-week period. The rabbits fed the cholesterol diet showed decreased activity of the erythrocyte GSH-Px compared with the rabbits fed the basal diet. The GSH-Px activity was significantly higher in the rabbits fed the CH + SR diet than in those on the CH diet. The erythrocyte SOD activity was also significantly decreased in the rabbits on the CH diet. However, the CH + SR group rabbits showed significantly enhanced erythrocyte SOD activity. The SOD level in the CH + SR rabbits was 34.91 U/ml, which was a 23% increase (p ≤ 0.05) in relation to the results for the CH group and only 15% diminished in relation to the control group. These results suggest that the dietary supplementation of skullcap root may improve rabbit antioxidant systems and protect against the risks from a high-cholesterol diet.
|Journal series||Journal of Animal Physiology and Animal Nutrition, ISSN 0931-2439, e-ISSN 1439-0396, (A 30 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Antioxidant enzymes; Blood parameters; Rabbit; Skullcap root|
|Publication indicators||= 11; = 11; : 2011 = 0.739; : 2011 = 0.855 (2) - 2011=1.068 (5)|
|Citation count*||14 (2020-08-06)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.