Electrochemotherapy combined with standard and CO2 laser surgeries in Canine oral melanoma
Julita Kulbacka , Joanna Paczuska , Nina Rembiałkowska , Jolanta Saczko , Zdzisław Kiełbowicz , Wojciech Kinda , Bartłomiej Liszka , Małgorzata Kotulska , Bor Kos , Damijan Miklavcic , Natasa Tozon , Maja Čemažar
AbstractOral melanomas commonly occur in elderly dogs resulting in darkly pigmented areas of the mouth, tongue and gums. The main object of this study was a severe melanoma diagnosed in the jaw of a 15-year-old dog and its palliative treatment with electrochemotherapy. The tumour spread throughout the jaw including bones. Electrochemotherapy (ECT) with bleomycin and calcium solution (CaCl2) was combined with standard and CO2 laser surgeries. The treatment resulted in good local control of the tumour mass after one ECT session with bleomycin and a second ECT session with calcium ions solution. ECT significantly reduced bleeding and enhanced success of the surgery. The combination of ECT with surgical debulking resulted in rapid recovery and regaining of physiological activities, including normal feeding by the dog. This case demonstrates that the protocol combining ECT and surgery is promising in palliative melanoma treatment.
|Other language title versions||Elektrokemoterapija v kombinaciji s standardno in lasersko co2 kirurgijo pasjih ustnih melanomov|
|Journal series||Slovenian Veterinary Research, ISSN 1580-4003, (A 20 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||oral melanoma; CO2 laser; electrochemotherapy; bleomycin; calcium ions; ustni melanom; laser CO2; elektrokemoterapija; bleomicin; kalcijevi ioni|
|Internal identifier||64655; PX-5a5f139bd5defae3633fbb92|
|License||Journal (articles only); published final; ; after publication|
|Score||= 20.0, 13-07-2020, ArticleFromJournal|
|Publication indicators||= 2; = 3; : 2016 = 0.161; : 2017 = 0.25 (2) - 2017=0.322 (5)|
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