Expression of Periostin in Mammary Cancer Cells of Female Dogs
Paulina Borecka , Rafał Ciaputa , Izabela Janus , Joanna Bubak , Aleksandra Piotrowska , Katarzyna Ratajczak-Wielgomas , Marzenna Podhorska-Okołów , Piotr Dzięgiel , Marcin Nowak
AbstractBackground/Aim: Periostin (POSTN) has a significant role in proliferation and migration of tumour cells as well as tumour progression. This study aimed to determinate POSTN expression in cancer cells in malignant and benign tumours of the mammary gland in female dogs. Materials and Methods: All together 83 cancers, 24 adenomas and 7 unchanged fragments of the mammary glands of bitches were investigated. Immunohistochemistry was performed using anti-POSTN, Ki-67 and HER2 antibodies. Results: POSTN expression was observed in cancer cells in 31.3% of malignancies and 12.5% of benign tumours. A significantly positive correlation between expression of POSTN in cancer cells and the degree of histological malignancy, expression of Ki-67 antigen and expression of POSTN in CAFs was found. Conclusion: The obtained results suggest the possible participation of POSTN in the process of carcinogenesis and progression of mammary tumors in bitches.
|Journal series||In Vivo, ISSN 0258-851X, e-ISSN 1791-7549, (N/A 40 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Periostin, carcinoma, adenoma, bitches, dog|
|License||Journal (articles only); published final; ; with publication|
|Score||= 40.0, 28-04-2021, ArticleFromJournal|
|Publication indicators||= 0; = 0; : 2018 = 0.548; : 2019 = 1.541 (2) - 2019=1.397 (5)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.