Cornelian cherry extract ameliorates osteoporosis associated with hypercholesterolemia in New Zealand rabbits
Beata Nowak , Agnieszka Matuszewska , Magdalena Tomanik , Jarosław Filipiak , Alicja Kucharska , Narcyz Piórecki , Diana Jędrzejuk , Krzysztof Zduniak , Małgorzata Trocha , Marek Bolanowski , Adam Szeląg , Tomasz Sozański
AbstractBackground. Results of animal studies show that a high-cholesterol diet increases bone resorption and decreases bone formation, thus leading toosteoporosis. Previously, wereported onthebeneficial influence ofCornelian cherry (Cornus mas L.) fruit onlipid profile inananimal model ofdiet-induced hipercholesterolemia. Objectives. To investigate the influence of Cornus mas L. extract and loganic acid (LA) on cholesterolinduced bone changes. Material and methods. The study was conducted on50 New Zealand rabbits. The animals were given either standard chow (group P) or the same standard chow enriched with 1% cholesterol (other groups). Additionally, thegroup CHOL+EX received Cornus masL. extract, group CHOL+LA – loganic acid, and group CHOL+SIM – simvastatin. Serum concentration ofbone turnover markers, bone mineral density (BMD) and bone micro-computed tomography (microCT) were assessed. Results. In the CHOL group, a decrease in osteocalcin (OC) and an increase in C-terminated telopeptide of type I collagen (CTX) levels were detected (CHOL vs P 0.674 ±0.159 ng/mL vs 1.003 ±0.297 ng/mL and 10.049 ±1.276 ng/mL vs 7.721 ±1.187 ng/mL, respectively). The EX and LA ameliorated cholesterolinduced changes in serum OC (0.857 ±0.160 ng/mL and 1.103 ±0.356 ng/mL, respectively) and CTX (7.735 ±1.045 ng/mL and 8.128 ±1.106 ng/mL, respectively). There was a significant decrease in femoral BMD inCHOL group (0.429±0.11g/cm² vs 0.449±0.020g/cm²). TheEX and LA ameliorated those changes (0.458±0.016g/cm² and 0.449±0.021g/cm², respectively). The microCT revealed increased bone volume ratio (BV/TV) and trabecular thickness (Tb.Th.) intheCHOL+EX group. Conclusions.Cornus mas L. inhibited bone resorption and stimulated bone formation, thereby preventing thedevelopment of cholesterol-induced osteoporosis.
|Journal series||Advances in Clinical and Experimental Medicine, ISSN 1899-5276, e-ISSN 2451-2680, [1230-025X], (N/A 40 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||osteoporosis, cholesterol, bone mineral density, bone micro-computed tomography, CornusmasL.|
|License||Journal (articles only); published final; ; with publication|
|Score||= 40.0, 20-04-2021, ArticleFromJournal|
|Publication indicators||= 0; = 0; : 2018 = 0.648; : 2019 = 1.514 (2) - 2019=1.504 (5)|
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