Antimicrobial chloro-hydroxylactones derived from the biotransformation of bicyclic halolactones by cultures of Pleurotus ostreatus
Małgorzata Grabarczyk , Wanda Mączka , Katarzyna Wińska , Barbara Żarowska , Gabriela Maciejewska , Elżbieta Gębarowska , Stanisław Jerzy Pietr
AbstractThe aim of this research was to test the ability of cultures of edible fungi to biotransform three bicyclic halolactones. The substrates (2-chloro-, 2-bromo- and 2-iodo-4,4,6,7-tetramethyl-9-oxabicyclo[4.3.0]nonan-8-one) received by means of synthesis were transformed by oyster mushroom Pleurotus ostreatus and edible mushrooms of the genus Armillaria mellea, Marasmius scorodonius and Laetiporus sulfureus. The substrates were converted to hydroxyl derivatives only by the cultures of oyster mushroom. Out of seven strains of Pleurotus ostreatus - three were capable of hydroxylation of all substrates with the most effective conversion of chlorolactone. Bromo- and iodolactone were transformed to a small extent. Four new chloro-hydroxylactones were obtained as biotransformation products. The structures of substrates and products were established on the basis of spectroscopic data. Studies of antimicrobial activity performed on reference strains of pathogenic microorganisms showed that halolactones caused complete inhibition of growth of A. alternata and F. linii strains. On the other hand, chloro-hydroxylactones were able to completely inhibit the growth of A. alternata and F. linii strains and also C. albicans strain.
|Journal series||Bioorganic Chemistry, ISSN 0045-2068, e-ISSN 1090-2120, (N/A 100 pkt)|
|Publication size in sheets||0.5|
|Keywords in English||Biotransformations, Halolactones, Hydroxylation|
|ASJC Classification||; ; ;|
|Score||= 100.0, 26-02-2021, ArticleFromJournal|
|Publication indicators||= 1; = 0; : 2018 = 1.21; : 2019 = 4.831 (2) - 2019=4.567 (5)|
|Citation count*||2 (2021-05-13)|
* presented citation count is obtained through Internet information analysis and it is close to the number calculated by the Publish or Perish system.