Tregitopes regulate the tolerogenic immune response and decrease the foetal death rate in abortion-prone mouse matings
Anna Ewa Kędzierska , Daria Lorek , Anna Sławek , Anna Chełmońska-Soyta
AbstractThe imbalance in immune tolerance may cause the variety of reproductive failures. An intravenous immunoglobulin infusion (IVIg) therapy is used to improve the live birth rate in women sufering from recurrent pregnancy loss, recurrent spontaneous abortions and recurrent implantation failures. However, the results of IVIg studies are still inconclusive as IVIg infusion in women sufering from pregnancy loss is sometimes inefective. One of the mechanisms of action of this treatment is inhibition of B cells diferentiation and expansion of Tregs and secretion of interleukin 10. It was proposed that immunomodulatory efects of IVIg may be attributed to tregitopes - self-IgG-derived epitopes present in the structure of immunoglobulins. Similarly to IVIg, tregitopes cause the expansion of Tregs and secretion of antigen-specifc efector cytokine response. Here, we studied whether the administration of mouse tregitope 167 and/or 289 can prevent abortions in mouse abortion-prone mouse matings. We revealed that tregitopes reduce the foetal death rate. This may be driven by observed higher pool of peripheral Tregs, increased production of IL-10 by Tregs and Bregs and/or maintaining the tolerogenic phenotype of antigen-presenting cells. We believe that our fndings may indicate a potential alternative to IVIg for therapeutic intervention in case of pregnancy failures.
|Journal series||Scientific Reports, ISSN 2045-2322, (N/A 140 pkt)|
|Publication size in sheets||0.6|
|License||Journal (articles only); author's original; ; after publication|
|Score||= 140.0, 15-09-2020, ArticleFromJournal|
|Publication indicators||= 0; : 2016 = 1.401; : 2018 = 4.011 (2) - 2018=4.525 (5)|
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